Endoribonuclease-prepared siRNAs (esiRNAs) are pools of siRNAs resulting from cleavage of long double-stranded RNA (dsRNA) with Escherichia coli RNase III.
Our MISSION esiRNA products are ideal for simple, cost-effective RNAi screening. MISSION esiRNA products are available for individual mouse and human genes, custom libraries – including the human kinase library, and genome-scale mouse and human libraries.
MISSION esiRNA will reduce target mRNA levels by 70% or greater in cultured cells, when transfected at 30 nM or greater. If the esiRNA does not achieve 70% target knockdown, Sigma will provide an additional esiRNA for that target gene free of charge.
More information on Sigma’s esiRNA products and how to place an order.