Simple, efficient, targeted genome editing via the CompoZr™ Zinc Finger Nuclease (ZFN) technology allows easy creation of novel cell lines and model organisms with precise and heritable gene additions, deletions, or modifications.
ZFNs are a class of engineered DNA-binding proteins that create double-strand breaks in DNA at specific locations. These double-strand breaks stimulate natural DNA repair processes (homologous recombination and non-homologous end joining, NHEJ). These processes can be used to generate precisely targeted genomic edits for cell lines with targeted gene deletions, integrations or modifications.
This powerful, breakthrough technology holds great promise for Stem Cell Research, as well as the broader life science community.