Sigma’s epigenetics portfolio includes products for studying DNA methylation, chromatin modifications and RNA regulation.
The Imprint™ line of kits streamline and simplify the workflow for bisulphite modification, global DNA methylation quantification and chromatin-immunoprecipitation. Sigma also carries small molecules inhibitors and activators for methyltransferases, HATs and HDACs as well as a broad range of antibodies for gene regulation including histone modification, chromatin modification, transcription factors, transcription regulators, RNA regulation and nuclear proteins. Sigma has leading functional genomics technologies including RNAi tools for gene silencing (siRNA, shRNA, miRNA) and cutting-edge systems for gene editing and gene knockout targeting genes.